Nutrition, metabolism, and cardiovascular diseases
This dual mechanism earned it FDA approval under the brand names Mounjaro (for type 2 diabetes) and Zepbound (for obesity)
The nail bed, underlying connective tissue, distal phalanx, and ligaments provide the supporting structures of the nail apparatus
DOI: 10.1016/j.ejmech.2019.06.010
The STEP trials (semaglutide) and SURMOUNT trials (tirzepatide) enrolled thousands of participants and demonstrated that GLP-1 therapy produces meaningful, sustained weight loss across diverse populations, with acceptable safety profiles when used under medical supervision
The restrictions are, in women, due to the potential for birth defects in children born of women of childbearing age